VEGFR-3 BINDING PEPTIDES AND THEIR USE FOR INHIBITING ANGIOGENESIS

摘要

The present invention relates to the diagnostics, evaluation, and therapeuti c intervention of disorders mediated by the activity of cell surface receptor VEGFR-3, which activity often is stimulated by VEGFR-3 ligands VEGF-C and VE GF- D. More particularly, the present invention identifies novel methods and compositions for the inhibition of VEGF-C/D binding to VEGFR-3. The compositions of the present invention will be useful the inhibition of angiogenesis and lymphangiogenesis.