| 摘要 |
PURPOSE:To obtain a medicine for external use, having strong activities and useful as an antiinflammatory and antipruritic agent having high safety. CONSTITUTION:This antiinflammatory and antipruritic agent contains a solvent extract from a steam distillation residue of a plant belonging to the genus Mentha of the family Labiatae, e.g. Mentha aquatica L., Mentha piperta L., Mentha pulegium L., Mentha rotundifolia (L.) Huds., Mentha spicata L. or Mentha citrata (Ehrh.) Briq. in an amount of 0.01-10.0wt.%, preferably 0.1-5.0wt.% expressed in terms of solids. Water, benzene, diethyl ether, chloroform, methylene chloride, ethyl acetate, butyl acetate, acetone, methanol, ethanol, butanol and 1,3-butylene glycol are cited as an extracting solvent and methanol, ethanol, butanol and a mixed solvent thereof are preferred. The ethanol extract essence, an extract essence prepared by partitioning the extract essence between hexane and hydrous ethanol and extracting the essence into a hydrous methanol layer and further an extract essence obtained by treating the essence with a styrene-divinylnbenzene copolymeric polymer adsorbent column chromatography and eluting the adsorbed substance with a 50% ethanol are especially preferred. |
