PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES

摘要

Compounds of formula (I): [wherein: A is a pyrrole ring; R<1> is an optionally substituted aryl or heteroaryl group; R<2> is an optionally substituted nitrogen-containing heteroaryl group; and R<3> is formulae (IIa), (IIb) or (IIc), wherein m is 1 or 2, one of D and E is nitrogen and the other is >C(R<5>)- (wherein R<5> is hydrogen, a Substituent PROPORTIONAL or a Substituent beta ), B is a nitrogen-containing 4- to 7-membered heterocyclic ring, and R<4> is from 1 to 3 substituents from Substituent group PROPORTIONAL , substituent group beta and Substituent group gamma ; PROVIDED THAT R<1> and R<3> are bonded to the two atoms of said pyrrole ring which are adjacent to the atom of the pyrrole ring to which said substituent R<2> is bonded; Substituent group PROPORTIONAL consists of hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio and halogeno alkythio groups and groups of formula NR<a>R<b> (wherein R<a> and R<b> are hydrogen, alkyl, alkenyl, alkynyl, aralkyl and alkylsulfonyl, or R<a> and R<b>, taken together with the nitrogen atom to which they are attached, form a heterocyclyl); Substituent group beta consists of optionally substituted alkyl, alkenyl and alkynyl groups, and aralkyl and cycloalkyl groups; Substituents group gamma consists of oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsufinyl, alkylsulfonyl, optionally substituted aryl, optionally substituted aryloxy, alkylidenyl and aralkylidenyl groups] have excellent activity against the production of inflammatory cytokines.