| 发明名称 |
SYMMETRICALLY DISUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING POLY (ADP-RIBOSE) GLYCOHYDROLASE, AND METHODS FOR THEIR USE |
| 摘要 |
Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds. |
| 申请公布号 |
WO02057211(A1) |
申请公布日期 |
2002.07.25 |
| 申请号 |
WO2001US11623 |
申请日期 |
2001.04.10 |
| 申请人 |
GUILFORD PHARMACEUTICALS, INC. |
发明人 |
LI, JIA-HE;FERRARIS, DANA, V.;KLETZLY, PAUL, W.;LI, WEIXING;WANG, ERIC, YANJUN;XING, AMY, D.;XU, WEIZHENG;ZHANG, JIE |
| 分类号 |
C07D295/10;A61K9/10;A61K9/107;A61K9/20;A61K9/48;A61K31/136;A61K31/166;A61K31/18;A61K31/216;A61K31/277;A61K31/352;A61K31/39;A61K31/4025;A61K31/444;A61K31/4545;A61K31/496;A61K31/5377;A61K47/30;A61P1/00;A61P1/04;A61P3/00;A61P3/10;A61P7/00;A61P9/00;A61P9/10;A61P13/12;A61P17/00;A61P17/02;A61P19/02;A61P19/10;A61P21/04;A61P25/00;A61P25/02;A61P27/02;A61P29/00;A61P31/04;A61P37/04;A61P43/00;C07C69/00;C07C69/76;C07C211/45;C07C225/16;C07C233/65;C07C233/66;C07C233/69;C07C233/73;C07C255/46;C07C311/37;C07C311/46;C07D207/32;C07D207/325;C07D213/30;C07D213/40;C07D295/12;C07D295/13;C07D295/18;C07D295/192;C07D311/82;C07D311/86;C07D327/08;C07D411/12;C07D411/14 |
主分类号 |
C07D295/10 |
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