发明名称 |
Novel protein, DNA coding for same and method of producing the protein |
摘要 |
A novel protein having inhibitory activity on the protease activity of hepatocyte growth factor (HGF) activator was purified and isolated, and its molecular weight (ca. 40,000 daltons) and its N-terminal and partial amino acid sequences were determined. A gene coding for the protein was cloned, and the gene DNA was incorporated into a vector, for transforming host cells. Cultivation of the transformant gave the desired protein. The protein can be used as an in vivo or in vitro control factor for HGF or HGF activator. It is also useful as an antigen to be used in producing an antibody to be used as means for kinetic studies of the protein, or as a standard in assay systems therefor.
|
申请公布号 |
US2002098537(A1) |
申请公布日期 |
2002.07.25 |
申请号 |
US20010765449 |
申请日期 |
2001.01.22 |
申请人 |
SHIMOMURA TAKESHI;KAWAGUCHI TOSHIYA;KITAMURA NAOMI;MIYAZAWA KEIJI |
发明人 |
SHIMOMURA TAKESHI;KAWAGUCHI TOSHIYA;KITAMURA NAOMI;MIYAZAWA KEIJI |
分类号 |
C07K14/81;C12N15/15;(IPC1-7):C07K14/00;C12P21/06;C07H21/04 |
主分类号 |
C07K14/81 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|