2-SUBSTITUTED DIBENZO[A,E]1,2,3-TRIAZOLO[4,5-C][7]ANNULEN-8-ONES AS GROWTH HORMONE SECRETAGOGUES

摘要

The invention relates to methods of treating or preventing diseases or conditions caused by deficiencies in growth hormone by administration of 2-substituted dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulen-8-ones. Such diseases or conditions include osteoporosis, osteopenia and obesity. Furthermore, the invention relates to methods of stimulating the release of growth hormone in a mammal by administration of 2-substituted dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulen-8-ones. Finally, the invention further relates to promoting bone growth in a mammal, particularly endocortical, periosteal, or cancellous bone growth, by administration of 2-substituted dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulen-8-ones.