REGULATION OF GENE EXPRESSION USING SINGLE-CHAIN, MONOMERIC, LIGAND DEPENDENT POLYPEPTIDE SWITCHES
摘要
Single chain, monomeric polypeptide gene switches are provided. The gene switches include ligand binding domains and at least one functional domain. Preferred functional domains are DNA binding domains and transcriptional regulating domains. Methods of regulating gene function using the switches are also provided.
申请公布号
WO0206463(A3)
申请公布日期
2002.07.25
申请号
WO2001EP08190
申请日期
2001.07.16
申请人
NOVARTIS AG;NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.;THE SCRIPPS RESEARCH INSTITUTE;BEERLI, ROGER;SCHOPFER, ULRICH;BARBAS, CARLOS, F.
