发明名称 |
METHODS FOR MINIMIZING BONE LOSS |
摘要 |
The present invention provides a method for minimizing the bone loss effect of a compound of formula (I) wherein R is -CH2CON(CH3) -n-CH2CH2CH2CH3 or -SO(CH2)3CF2CF3, or a pharmaceutically acceptable salt thereof, and wherein said formula (I) compound is administered to a mammal in need of treatment, comprising concurrently or sequentially administering to said mammal an effective amount of a compound of formula (II) wherein each R<1> is independently -H, -OH,-O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), or -OSO2(C4-C6 alkyl); and R<2> is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; or a pharmaceutically acceptable salt thereof. Also provided is a method for minimizing bone loss induced by the administration of formula (I) compound comprising concurrently or sequentially administering a bone anabolic agent. Pharmaceutical compositions are also provided.
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申请公布号 |
WO9639141(A1) |
申请公布日期 |
1996.12.12 |
申请号 |
WO1996US08810 |
申请日期 |
1996.06.05 |
申请人 |
ELI LILLY AND COMPANY;CULLINAN, GEORGE, J.;FONTANA, STEVEN, A.;FUCHS-YOUNG, ROBIN, S., L.;GLASEBROOK, ANDREW, L. |
发明人 |
CULLINAN, GEORGE, J.;FONTANA, STEVEN, A.;FUCHS-YOUNG, ROBIN, S., L.;GLASEBROOK, ANDREW, L. |
分类号 |
A61K31/38;A61K31/381;A61K31/40;A61K31/4025;A61K31/445;A61K31/4535;A61K31/535;A61K31/55;A61K31/565;A61K38/29;A61P15/00;A61P35/00;(IPC1-7):A61K31/445 |
主分类号 |
A61K31/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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