MODEL ANIMAL OF MESANGIAL CELL PROLIFERATIVE NEPHRITIS

摘要

An animal model for mesangial proliferative nephritis was provided using megsin transgenic animals. Transgenic mice constructed by using a megsin gene exhibits typical symptoms of mesangial proliferative nephritis associated with the expansion of the mesangial matrix, the deposition of an immune complexes, and an increase in mesangial cells. This animal model for mesangial proliferative nephritis is useful in analyzing the pathological conditions of chronic glomerular diseases and the screening for therapeutic agents.