| 摘要 |
PROBLEM TO BE SOLVED: To produce the subject compound which is useful as an intermediate for medicines or agrochemicals in high yield by reaction of a nitrile compound with an alcohol without isolation of its intermediate. SOLUTION: A compound bearing a nitrile group (acetonitrile) in an amount of 1 mole and an alcohol (methanol) in an amount of 0.7-5 moles (preferably 0.9-2 moles) are dissolved in a nonpolar solvent in the presence of an acid and subjected to the reaction between them. The acid used in this reaction is an inorganic acid such as hydrochloric acid and the amount of the acid is set to 0.7-5 moles per mole of the nitrile and the reaction temperature is -10-20 deg.C. In the reaction, the alcohol is sequentially added to 1 mole of the nitrile by 0.8-2 moles, preferably 0.9-1.5 mole and the reaction mixture is heated at 20-100 deg.C to effect the reaction. After completion of the reaction, the salt formed as a by-product is separated. |
