发明名称 |
Method for increasing the serum half-life of a biologically active molecule |
摘要 |
A method is provided for preparing a biologically active molecule having an increased serum half-life. The method involves conjugating a polymer such as polyethylene glycol to the biologically active molecule. Also provided are polypeptide drugs having an increased serum half-life, e.g., human urokinase plasminogen activator (human "uPA" or "hUPA") or a fragment or derivative thereof. Pharmaceutical compositions containing such molecules and methods of using them to treat uPA-mediated and uPA receptor-mediated disorders are also provided.
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申请公布号 |
US6423685(B1) |
申请公布日期 |
2002.07.23 |
申请号 |
US19990263117 |
申请日期 |
1999.03.05 |
申请人 |
CHIRON CORPORATION |
发明人 |
DRUMMOND ROBERT J.;ROSENBERG STEVE |
分类号 |
A61K38/00;A61K38/17;A61K47/48;C07K1/107;C07K14/315;C07K14/47;C07K14/705;C12N9/72;C12N9/96;(IPC1-7):A61K38/00;A61K39/385;C07K1/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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