发明名称 |
Method of decreasing radiation or radio-mimetic chemotherapy for hematopoietic pluripotent cell engraftment |
摘要 |
The present invention provides a method of engrafting donor mammalian hematopoietic pluripotent cells in a mammalian recipient using a decreased amount of radiation, comprising: (a) administering to the recipient at least one dosage of a hematopoietic growth factor; (b) subjecting the recipient to a low dosage of radiation; and (c) transplanting the donor hematopoietic pluripotent cells in the recipient, thereby engrafting the donor mammalian hematopoietic pluripotent cells in the mammalian recipient using a decreased amount of radiation. The invention also provides a method of engrafting donor mammalian hematopoietic pluripotent cells in a mammalian recipient using a decreased amount of radiomimetic compound, comprising: (a) administering to the recipient at least one dosage of a hematopoietic growth factor; (b) subjecting the recipient to a low dosage of radiomimetic compound; and (c) transplanting the donor hematopoietic pluripotent cells in the recipient, thereby engrafting the donor mammalian hematopoietic pluripotent cells in the mammalian recipient using a decreased amount of radiomimetic compound.
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申请公布号 |
US6423311(B1) |
申请公布日期 |
2002.07.23 |
申请号 |
US19990468727 |
申请日期 |
1999.12.21 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
MARDINEY, III MICHAEL;MALECH HARRY L. |
分类号 |
A61K38/00;A61K31/00;A61K35/14;A61K35/28;A61K38/18;A61K38/19;A61K45/00;A61P41/00;(IPC1-7):A01N63/00;C12P21/02;C12N5/00;C12N5/08;A61N1/30 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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