REDUCTION OF ADHESIONS USING CONTROLLED DELIVERY OF ACTIVE OXYGEN INHIBITORS

摘要

SOD and other active oxygen inhibitors are directly applied in combination w ith a barrier material at local sites of tissue injury to prevent or decrease formation of adhesions and undesirable profileration of cells. Preferred barrier materials are polymeric hydr ogels providing controlled release of AOI which are directly applied to the afflic ted tissue. Examples demonstrate the effects of SOD on p elvic adhesions in the rat when administered by intraperitoneal (IP.) bolus and by localized sustained release from a topically applied hy drogel system.