Novel derivatives of beta-amido- and beta-sulfonamidocarboxylic acid, process of their preparation and use as endothelin receptor antagonists

摘要

The invention relates to carboxylic acid derivatives of formula (I), in which the substituents have the following meanings: R<1> is tetrazol or a group (a); W and Z, can be identical or different and are nitrogen or methine, provided that if W and Z are methine, then Q is nitrogen; X is nitrogen or CR<9>; Y is nitrogen or CR<10>; Q is nitrogen or CR<11>, provided that if Q is nitrogen then X is CR<5> and Y is CR<10>; R<2> and R<3> are identical or different and are possibly substituted phenyl or naphthyl or phenyl or naphthyl which are linked in an ortho position via a direct bond, a methlyene, ethylene or ethenylene group, an oxygen or sulfur atom or a SO2-, NH- or N-alkyl group or possibly substituted C5-C6-cycloalkyl; R<4> is a rest (b) or (c); and R<5> is hydrogen, C1-C4-alkyl. The invention further relates to their preparation and their use as endothelin receptor antagonists. The invention also relates to compounds of formula (II) and a structural fragment of formula (d) in which the rests R<1>, R<2>, R<3>, R<4> and R<5> have the meanings given in claim no. 1 and to their use as structural elements in an endothelin receptor antagonist.