| 发明名称 |
Combination of radiotherapy and anti-angiogenic factors |
| 摘要 |
The present invention relates generally to the fields of angiogenesis and cancer therapy. More particularly, it concerns the use of anti-angiogenic factors in cancer therapy. The present invention demonstrates that angiostatin or endostatin can sensitize a cell to radiation therapy. Methods and compositions for inhibiting growth, sensitizing a cell to radiotherapy and treating cancer growth by first inhibiting angiogenesis and then employing radiotherapy are described.
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| 申请公布号 |
US6420335(B1) |
申请公布日期 |
2002.07.16 |
| 申请号 |
US19990334084 |
申请日期 |
1999.06.15 |
| 申请人 |
DANA FARBER CANCER INSTITUTE, INC.;ARCH DEVELOPMENT CORPORATION;BETH ISRAEL DEACONESS MEDICAL CENTER, INC. |
发明人 |
WEICHSELBAUM RALPH R.;SUKHATME VIKAS P.;KUFE DONALD W. |
| 分类号 |
C12N15/09;A61K38/00;A61K38/20;A61K38/36;A61K38/39;A61K38/46;A61K38/48;A61K45/00;A61K48/00;A61P9/00;A61P35/00;A61P43/00;(IPC1-7):A01N37/18;A01N5/10;A01N61/00;A01N5/00;C07K1/00 |
主分类号 |
C12N15/09 |
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