发明名称 |
Production of multimeric protein by cell fusion method |
摘要 |
The present invention features a method of producing a multimeric protein from a hybrid cell formed from the fusion of two or more cells, each of which cell is engineered to express one component of the multimeric protein, as well as a method for screening for successful fusion of the cells to produce a desired hybrid cell. The methods of the invention are widely applicable to the production of proteins having two or more components.
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申请公布号 |
US6420140(B1) |
申请公布日期 |
2002.07.16 |
申请号 |
US20010769070 |
申请日期 |
2001.01.24 |
申请人 |
ABGENIX, INC.;JAPAN TOBACCO INC. |
发明人 |
HORI NOBUAKI;DAVIS CLAUDE GEOFFREY;ZSEBO KRISZTINA M.;JAKOBOVITS AVA |
分类号 |
C07K14/00;C07K16/00;C07K16/24;C12N5/16;C12N5/26;C12N15/62;C12P21/04;(IPC1-7):C12P21/04;C12N15/00;C12N5/06;C12N5/12 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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