Hydroxamic acid derivatives, useful as metalloprotease inhibitors for the treatment of cancers, rheumatic disorders or neuropathological degenerative disorders, e.g. cerebral ischemia or epilepsy

摘要

Hydroxamic acid derivatives (I), their optical isomers and salts with acids and bases are new. Hydroxamic acid derivatives of formula (I), their optical isomers and salts with acids and bases are new. n = 0 - 2; R1 = R1a when n is zero, and is R1b when n is 1 or 2; R1a = -Ak-CO-NR'1aR''1a; R'1a = H; Ak = 1-6C alkylene; R''1a = 3-8C cycloalkyl or 1-6C alkyl (substituted by one or more heteroaryl groups); or NR'1aR''1a = form a nitrogen heterocycle; R1b = -Ak-CO-NR'1bR''1b; R'1b and R''1b = H, 3-8C cycloalkyl, 1-6C alkyl (optionally substituted by aryl, heteroaryl or cycloalkyl groups); R2 = aryl 1-6C alkyl or heteroaryl 1-6C alkyl; Ar = aryl or heteroaryl. An Independent claim is included for the preparation of (I).