ORTHO-ALKYLATION METHOD OF AROMATIC KETONE

摘要

PURPOSE: Provided is an ortho-alkylation method of an aromatic ketone, which applies an alkyl group selectively to the ortho position of the aromatic ketone by reacting the aromatic ketone with an olefin. CONSTITUTION: The ortho-alkylation method is performed by (1) reacting the aromatic ketone with an alkyl contained compound, such as an aliphatic or aromatic alkyl contained olefin, an internal olefin, or a diene compound, in the presence of a primary amine and a transition metal catalyst or by (2) reacting the aromatic ketone with the primary amine to produce a ketimine and then reacting the ketimine with the alkyl contained compound in the presence of the transition metal catalyst.