GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND USE THEREOF IN MEDICINES

摘要

Glucopyranosyloxypyrazole derivatives represented by the general formula (I) or pharmacologically acceptable salts thereof, which exibit human SGLT2 inhibiting activity, are improved in peroral absorbability, and are useful as preventive or therapeutic drugs for diseases due to hyperglycemia, e.g., diabetes, complications of diabetes, and obesity; and use of the compounds or the salts in medicines: (I) wherein R is hydrogen, lower alkyl, or a prodrug-constituting group; one of Q and T is a group of the general formula (II): (II) (wherein P is hydrogen or a prodrug-constituting group), and the other is lower alkyl or halogenated lower alkyl; and R<2> is hydrogen, lower alkyl, lower alkoxy, lower alkythio, halogenated lower alkyl, or halogeno, with the proviso that when R is hydrogen or lower alkyl, P is not hydrogen.