| 摘要 |
<p>The invention relates to a pharmaceutical composition for inducing an immune response directed against malignancies in a mammalian subject. The composition comprises as active ingredients autologous antigen presenting cell (APC) which were loaded with mixture of at least two allogenic tumor cell line lysates. Optionally, the composition of the invention may further comprise an IL-2 adjuvant. The invention further relates to a method for conferring immunity against a malignancy, in a mammalian subject in need, by administering an autologous antigen presenting cells (APC) loaded with a mixture of allogeneic cell lysates mixture, or a composition comprising the same to said subject. The invention further relates to the use of these loaded APC cells in the preparation of pharmaceutical composition for the treatment of malignant disorders, particularly, melanoma.</p> |
