发明名称 |
Methods for measuring therapy resistance |
摘要 |
The present invention concerns methods for measuring drug resistance by correlating genotypic information with phenotypic profiles. In one embodiment, a method for interpreting genotypic information is described wherein a genetic code is generated from a patient sample, a list of mutations known or suspect to play a role in the development of resistance to one or more drugs is obtained from the generated genetic code, a genotype database is interrogated for previous samples with similar mutations relating to said one or more drugs, a phenotype for said sample is located in a phenotype database, the mean change in inhibition is determined based on all the examples located in said phenotype database, a distribution of sensitivities of one or more drugs suitable for treating a specific indication is determined.
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申请公布号 |
US2002091664(A1) |
申请公布日期 |
2002.07.11 |
申请号 |
US20010836477 |
申请日期 |
2001.04.18 |
申请人 |
LARDER BRENDAN;BLOOR STUART;HERTOGS KURT;DEHERTOGH PASCALE ALFONS ROSA;MORTIER RUDY JEAN MARC |
发明人 |
LARDER BRENDAN;BLOOR STUART;HERTOGS KURT;DEHERTOGH PASCALE ALFONS ROSA;MORTIER RUDY JEAN MARC |
分类号 |
C12N15/09;A61P31/18;C12Q1/68;C12Q1/70;G06F7/00;G06F17/30;G06F19/18;G06F19/24;(IPC1-7):G06F7/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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