发明名称 |
Inhibiting DNA synthesis in T-lymphocytes, keratinocytes and TH2 cytokine production, comprises combined administration of dipeptidyl peptidase and alanyl-aminopeptidase inhibitors |
摘要 |
Inhibiting the activation and proliferation (DNA synthesis) of human T-lymphocytes or mononuclear cells and the production of TH2 cytokines comprises combined administration of dipeptidyl peptidase IV (DP IV) inhibitors and alanyl-aminopeptidase (aminopeptidase N, APN) inhibitors. The DP IV and APN inhibitors may be replaced by enzymes with the same substrate specificity. Independent claims are also included for the following: (1) the combined use of DP IV and APN inhibitors for the (super-)additive inhibition of the activation and proliferation (DNA synthesis) of human epidermal and follicular keratinocytes and those in the transition region between the skin and mucosa; (2) the combined use of DP IV and APN inhibitors, X-Pro-aminopeptidase (APP) inhibitors, ACE inhibitors and/or prolyloligopeptidase (POP) inhibitors for the (super-)additive inhibition of the activation and proliferation (DNA synthesis) of human T-lymphocytes or mononuclear cells; and (3) pharmaceutical preparations containing DP IV and APN inhibitors (or enzymes with the same substrate specificity) and optionally APP, ACE and/or POP inhibitors.
|
申请公布号 |
DE10100052(A1) |
申请公布日期 |
2002.07.11 |
申请号 |
DE2001100052 |
申请日期 |
2001.01.02 |
申请人 |
INSTITUT FUER MEDIZINTECHNOLOGIE MAGDEBURG GMBH, IMTM |
发明人 |
ANSORGE, SIEGFRIED;LENDECKEL, UWE;NEUBERT, KLAUS;REINHOLD, DIRK |
分类号 |
A61K38/55;(IPC1-7):A61K38/05;A61K31/198 |
主分类号 |
A61K38/55 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|