| 摘要 |
<p>Disclosed are nicotinanilide-N-oxide compounds, having the structure (I) and optical isomer, diastereomers, enantiomers and pharmaceutically acceptable salts thereof, wherein R1 is selected from R?5 and R5-(C¿1-C6heteroalkylene)- where R5 is selected from hydrogen, halogen, alkyl, heteroalkyl, aryl, heteroaryl, carbocycle aliphatic ring and heterocycle aliphatic ring, amino or hydroxy; R?2 and R3¿ are independently hydrogen, alkyl, heteroalkyl, aryl, aryl(akylene), heteroaryl, heteroaryl(alkylene), carbocycle, carbocycle(alkylene), heterocycle, and heterocycle(alkylene); each occurrence of R4 is independently selected from halogen, alkyl, heteroalkyl, aryl, heteroaryl, carbocyle aliphatic ring and heterocycle aliphatic ring, amino or hydroxy; and is 0, 1, 2 or 3, methods for their production, pharmaceutical compositions which include these compounds, and methods for their use in various therapies.</p> |
