| 摘要 |
Compounds according to the formula A-B-Z-W, wherein A is selected from (C6-C10)aryl-, or (C1-C9)heteroaryl-, which groups may be optionally substituted; B is selected from (a) O, NH, NR10, -(CH2)k-O-, -(CH2)k-N-, and -(CH2)k-NR10-, where R10is (C1-C6)alkyl and where k is 1 to 6 in each case, or where said group (i) through (iv) is optionally substituted by 1 to 4, preferably 1 to 2, groups selected from (C1-C6)alkyl, halo, and (C1-C6)alkyl optionally substituted by 1 to 3 halo atoms wherein one of carbon atoms C1, C2, C3 and C4 of said piperidine or piperazine group is optionally replaced by a carbonyl group; Z and W are as herein described; and pharmaceutically acceptable salts, solvates or hydrates thereof; pharmaceutical compositions thereof; and methods useful to facilitate secretion of growth hormone(GH) in mammels.
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