| 摘要 |
In this invention we describe a mucin-containing delivery vehicle for the transport of biomolecules. This vehicle is used to carry and deliver biomolecules such as DNA (deoxyribonucleic acid), RNA (ribonucleic acid), PNA (peptide nucleic acid), polynucleotides, proteins, peptides, lipids, glycoproteins, glycolipids, carbohydrates or a combination of these biomolecules into organisms, cells and interstitial spaces in organisms. The delivery vehicle described in the present invention is comprised of a mucin component, which consists of any mucin or mucin-like moieties and of biomolecules of the same type or of different types. The mucin component of the biomolecules transport vehicle serves to enhance the process of biomolecules transport and delivery. The mucin-based delivery vehicle described in the present invention can be used for biochemical, biomedical, therapeutic or other applications including, but not limited to, delivery of DNA, RNA, PNA, polynucleotides and proteins into cells; gene delivery applications; in vivo, ex vivo or in vitro gene therapy; vaccination of organisms; genetic vaccination of organisms; and, delivery of pharmaceutical products containing biomolecules.
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