发明名称 |
INDUCING ANTIBODY RESPONSE AGAINST SELF-PROTEINS WITH THE AID OF FOREIGN T-CELL EPITOPES |
摘要 |
A novel method for utilizing the immune apparatus to remove and/or down-regulate self-proteins. The method consists in providing a self-protein analog by molecular biological means by substitution of one or more peptide fragments of the self-protein by corresponding number of peptides known to contain immunodominant foreign T-cell epitopes, said substitution being carried out so as to essentially preserve the overall tertiary structure of the original self-protein. This render the self-protein immunogenic and leads to a rapid induction of high-titered autoantibodies against the native self-proteins. The modulated self-proteins can be used to prepare vaccines against undesirable proteins in humans or animals, said vaccine being useful as therapeutics against a number of diseases, e.g. cancer, chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel diseases, allergic symptoms or diabetes mellitus.
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申请公布号 |
US2002090379(A1) |
申请公布日期 |
2002.07.11 |
申请号 |
US19970955373 |
申请日期 |
1997.10.21 |
申请人 |
MOURITSEN SOREN;ELSNER HENRIK |
发明人 |
MOURITSEN SOREN;ELSNER HENRIK |
分类号 |
A61K39/00;A61P1/00;A61P3/08;A61P3/10;A61P29/00;A61P35/00;A61P37/08;C07K14/00;C07K14/525;C07K14/74;C07K14/77;C07K19/00;(IPC1-7):A61K39/00;A61K39/38;A61K39/385;C07K1/00;C07K17/00;G01N33/53 |
主分类号 |
A61K39/00 |
代理机构 |
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地址 |
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