发明名称 |
COMPOUNDS FOR INHIBITING DISEASES AND PREPARING CELLS FOR TRANSPLANTATION |
摘要 |
Methods and compositions are provided for inhibiting, preventing and treating amyloid depositions, e.g. in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. Accordingly, the compositions and method of the invention are useful for inhibiting diabetes. The invention also provides a process for the preparation of cells suitable for transplantation into a mammal, which cells are capable of forming fibrils, said process comprising contacting the cells with an inhibitor of fibril formation. In particular the process prepares cells for use in a method of treating diabetes. Also provided are a culture medium comprising the inhibitor more particularly selected from the group consisting of 3-(3-hydroxy-1-propy)amino-1-propanesulfonic acid; DL-2-amino-5-phosphovaleric acid; 4-Phenyl-1-(3'-sulfopropyl)-1,2,3,6-tetrahydropyridine, cyclohexylsulfamic acid, O-phospho-L-serine, hexafluoroglutaric acid, 8-methoxyquinoline-5-sulfonic acid, 3-amino-2hydroxy-1-propanesulfonic acid, and 3-dimethylamino-1-propanesulfonic acid and 1,2,3,4-tetrahydroisoquinoleine.
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申请公布号 |
WO0103680(A3) |
申请公布日期 |
2002.07.11 |
申请号 |
WO2000GB02623 |
申请日期 |
2000.07.07 |
申请人 |
ISIS INNOVATION LIMITED;NEUROCHEM, INC.;QUEENS UNIVERSITY AT KINGSTON;CLARK, ANNE;FRASER, PAUL;VERCHERE, BRUCE;GUPTA, AJAY;MIGNEAULT, DAVID;SZAREK, WALTER;WEAVER, DONALD |
发明人 |
CLARK, ANNE;FRASER, PAUL;VERCHERE, BRUCE;GUPTA, AJAY;MIGNEAULT, DAVID;SZAREK, WALTER;WEAVER, DONALD |
分类号 |
A61K31/00;A61K31/185;A61K31/194;A61K31/44;A61K31/47;A61K31/472;A61P3/00;A61P25/00;C07K14/47;(IPC1-7):A61K31/145;A61K31/662;A61K31/451;A61K31/445 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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