发明名称 |
Method of reducing morbidity and the risk of mortality. |
摘要 |
This invention relates to methods, pharmaceutical compositions and kits useful in reducing cardiovascular morbidity and the risk of mortality in men and post-menopausal women and morbidity and the risk of mortality in post-menopausal women from the combined reduction of breast cancer, osteoporosis and cardiovascular disease by the administration of estrogen agonists / antagonists. The compositions are comprised of an estrogen agonist / antagonist and a pharmaceutically acceptable vehicle, carrier or diluent. The compositions and methods of treatment are effective while substantially reducing the concomitant liability of adverse effects associated with estrogen administration. |
申请公布号 |
ZA200100276(B) |
申请公布日期 |
2002.07.10 |
申请号 |
ZA20010000276 |
申请日期 |
2001.01.10 |
申请人 |
PFIZER PRODUCTS INC. |
发明人 |
DAY, WESLEY, WARREN;LEE, ANDREW, GEORGE;THOMPSON, DAVID, DUANE |
分类号 |
C07D295/08;A61K31/00;A61K31/138;A61K31/40;A61K31/403;A61K31/404;A61K31/435;A61K31/4418;A61K31/4427;A61K31/4439;A61K31/4453;A61K31/451;A61K31/453;A61K31/472;A61K31/4725;A61K31/475;A61K31/517;A61K31/55;A61P5/30;A61P9/00;A61P9/10;A61P19/10;A61P35/00;A61P43/00;C07D209/12;C07D213/64;C07D217/16;C07D311/60;C07D401/04 |
主分类号 |
C07D295/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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