发明名称 |
COMPOSITIONS AND METHOD FOR TREATMENT OF CANCER USING MONOCLONAL ANTIBODY AGAINST GD3 GANGLIOSIDE TOGETHER WITH IL-2 |
摘要 |
Cell surface gangliosides are presumed to play a role in cell growth and differentiation. Using monoclonal antibodies directed against G D3, a disialoganglioside expressed predominantly by cells of neuroectodermal origin, we have found that G D3 is expressed by a subpopulation of cells of the immune system including: a) fetal thymocytes in subcortical regions and near vessels, 2) lymph node lymphocytes in interfollicular areas and near vessels, and 3) a small subset of T cells in the peripheral blood. Mouse monoclonal antibodies (two IgGs, one IgM and F(ab')2 fragments) reacting with G D3 were found to stimulate proliferation of T cells derived from peripheral blood. Proliferation induced by binding to G D3 could be augmented by exogenous IL-2, PMA, PHA or Protein A.
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申请公布号 |
CA1341374(C) |
申请公布日期 |
2002.07.09 |
申请号 |
CA19870551669 |
申请日期 |
1987.11.12 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
OLD, LLOYD J.;CHAPMAN, PAUL;MILLER, GLENN;HOUGHTON, ALAN N.;WELTE, KARL |
分类号 |
A61K38/00;A61K39/395;A61P35/00;(IPC1-7):C12N5/12;A61K38/20 |
主分类号 |
A61K38/00 |
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