BISPECIFIC ANTIBODIES

摘要

The present invention discloses a bispecific antibody (BAb) comprising two antibodies, each of which has a binding specificity to a different epitope situated on the surface of a target structure. Each of said antibodies has a relatively low binding affinity for its respective epitope. The BAbs produced according to the present invention have much lower affinity for cross-reactive non-target tissue due to the lower affinity of the MAbs used to produce them. These BAbs still provide high avidity for target tissue due to the cumulative nature of the binding interactions.