| 发明名称 |
Antibody conjugate kits for selectively inhibiting VEGF |
| 摘要 |
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet have improved safety due to their specificity. The present invention thus provides new antibody-based compositions, methods and combined protocols for treating cancer and other angiogenic diseases. Advantageous immunoconjugate and prodrug compositions.
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| 申请公布号 |
US6416758(B1) |
申请公布日期 |
2002.07.09 |
| 申请号 |
US20000561526 |
申请日期 |
2000.04.28 |
| 申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAX SYSTEM |
发明人 |
THORPE PHILIP E.;BREKKEN ROLF A. |
| 分类号 |
C12N15/02;A61K39/395;A61K45/00;A61K47/48;A61P9/10;A61P27/02;A61P35/00;A61P43/00;C07K5/103;C07K14/52;C07K16/22;C07K16/24;C07K16/30;C12N5/02;C12N5/10;C12P21/08;(IPC1-7):A61K38/36 |
主分类号 |
C12N15/02 |
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