Method of using multicellular particulates to analyze malignant or hyperproliferative tissue

摘要

A comprehensive and integrated system for monitoring (identifying, tracking and analyzing) an individual patient's malignancy or hyperproliferative syndrome through the duration of a malignancy or hyperproliferative syndrome as to a specific patient is provided. Specimens of a patient's cells are collected and mechanically separated into cohesive multicellular particulates. A tissue culture monolayer is grown from the multicellular particulates to form a prime culture, and the tissue culture is monitored over a period of time. The invention allows for study of the effect of various treatment methods on cellular production of vascular endothelial growth factor.