发明名称 TETRAHYDRO-(BENZO OR THIENO)-AZEPINE-PYRAZINE AND TRIAZINE DERIVATIVES AS MGLUR 1 ANTAGONISTS
摘要 The invention relates to compounds which are represented by general formula (I) wherein R1~, R2~, R3~ R4~, X and Y are as defined in the specification, as well as pharmaceutically acceptable salts thereof. The invention further relates to medicaments containing these compounds and to a process for their preparation. The compounds possess affinity towards metabotropic glutamate receptors and are therefore useful in the treatment or prevention of acute and/or chronic neurological disorders.
申请公布号 CA2432077(A1) 申请公布日期 2002.07.04
申请号 CA20012432077 申请日期 2001.12.11
申请人 F. HOFFMANN-LA ROCHE AG 发明人 BINGGELI, ALFRED;MUTEL, VINCENT;WILHELM, MAURICE;MAERKI, HANS-PETER;WOSTL, WOLFGANG
分类号 A61K31/495;A61K31/53;A61K31/55;A61P1/08;A61P9/10;A61P13/02;A61P19/00;A61P21/00;A61P21/04;A61P25/00;A61P25/04;A61P25/06;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/36;A61P27/02;A61P43/00;C07D403/04;C07D495/04;(IPC1-7):C07D495/04 主分类号 A61K31/495
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