PROCESS TO INCREASE THE CONCENTRATION OF MEIOSIS-ACTIVATING STEROLS (MAS) IN THE CHOLESTEROL SYNTHESIS AND THE USE OF POTENT INHIBITORS IN THE PROCESS

摘要

The invention relates to a process to increase the concentration of meiosis-activating sterols (MAS) in the cholesterol synthesis wherein potent inhibitors where added, the use of potent inhibitors in the cholesterol synthesis, a pharmaceutical composition comprising the potent inhibitors and the use of the inhibitors for the microbiology production of meiosis-activating sterols (MAS). In the process of the invention the DELTA 24-reduction or/and 4 alpha -demethylation in the cholesterol synthesis are inhibited. As a result of this inhibition the concentration of FF-MAS and/or T-MAS as meiosis-activating sterols (MAS) are increased.