HUMAN FGF23 PROTEIN MUTANT LOWERING BLOOD PHOSPHORUS LEVEL

摘要

A full-length cDNA encoding human FGF23 protein is isolated and a mutant of this cDNA with a single amino acid substitution is constructed by a mutagenesis method. When expressed in vivo, this mutant exerts an effect of lowering blood phosphorus level. It is expected that this mutant and DNA encoding the same are applicable to remedies for hyper phosphatemia or gene therapy therefor.