发明名称 |
HERPEVIRUS REPLICATION DEFECTIVE MUTANTS |
摘要 |
A herpesvirus vaccine comprising a mutated herpesvirus suspended in a pharmaceutically acceptable carrier. The mutated herpesvirus is capable of infecting cells of the mammal to be vaccinated, but incapable of completing a replicative cycle, and it is capable of eliciting a protective immune response in that mammal. The mutated herpesvirus is also capable of treating immunomodulatory or immunoregulatory diseases. The mutation occurs in at least one gene encoding a protein essential for replication of the virus, so that the mutation renders the virus replication defective.
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申请公布号 |
US2002086035(A1) |
申请公布日期 |
2002.07.04 |
申请号 |
US19980034464 |
申请日期 |
1998.03.04 |
申请人 |
KNIPE DAVID M.;FINBERG ROBERT;SIBER GEORGE |
发明人 |
KNIPE DAVID M.;FINBERG ROBERT;SIBER GEORGE |
分类号 |
A61K39/00;A61K39/245;C07K14/03;C07K14/035;C12N7/04;(IPC1-7):A61K39/245;A61K39/12;A61K39/02 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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