| 摘要 |
The present disclosure provides methods for inducing tolerance in a recipient to a mismatched graft of an organ, tissue and/or cells. By receiving the recipient's thymus and providing hematopoietic stem cells from the donor, the previously "foreign" matter becomes recognized as "self" in the recipient and is not rejected. the patient's T cell population is depleted. In a preferred embodiment the hemapoietic stem cells are CD34+. The recipient's thymus is reactivated by disruption of sex steroid mediated signaling to the thymus. In a preferred embodiment this disruption is created by administration of LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies, anti-LHRH vaccines or combinations thereof. |
