| 摘要 |
A process is described for preparing 2-methoxy-4-methyl-6-methylamino-1,3-5-triazine in three steps consisting of: (a) the preparation of zinc bis(imino-bis-carbimic acid methyl ester); (b) subsequent reaction of the intermediate from step (a) with acetic anhydride to give 2,4-dimethoxy-6-methyl-1,3,5-triazine; and (c) reaction of the 2,4-dimethoxy-6-methyl-1,3,5-triazine formed in step (b), with methylamine to give the end product, which comprises preparing in step (a) zinc bis(imino-bis-carbimic acid methyl ester) by reaction of sodium dicyanamide with zinc acetate in methanol, then reacting in step (b) the reaction product formed in step (a) in dried or methanol-moist form, with acetic anhydride at from 30 to 80 DEG C without addition of a solvent and finally, after removal of the byproducts from steps (a) and (b), converting in step (c) 2,4-dimethoxy-6-methyl-1,3,5-triazine by reaction with methylamine in methanolic solution at from 0 to 30 DEG C into the end product. In this manner, the desired end product can be prepared in good yields and in high purity, without the need to use highly dangerous zinc dicyanamide in step (a), and also without the need to add a solvent in step (b). |
