发明名称 |
CYTOTOXIC AGENTS COMPRISING TAXANES AND THEIR THERAPEUTIC USE |
摘要 |
A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. Novel sulfur-containing taxanes.
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申请公布号 |
US2002086897(A1) |
申请公布日期 |
2002.07.04 |
申请号 |
US20020059022 |
申请日期 |
2002.01.30 |
申请人 |
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发明人 |
CHARI RAVI V. J.;BLATTLER WALTER A. |
分类号 |
C07D305/08;A61K31/337;A61K31/452;A61K31/496;A61K31/5377;A61K47/48;A61P35/00;A61P43/00;C07D305/14;C07D413/02;C07K16/28;C07K16/32;(IPC1-7):A61K31/337;C0735/14 |
主分类号 |
C07D305/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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