RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS.

摘要

This invention concerns the compounds of formula (I), prodrugs, N-oxides, addition salts, quaternary amines, metal complexes or stereochemically isomeric forms thereof wherein -a1=a2-a3=a4- is a radical of formula -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N- wherein each hydrogen atom may optionally be substituted; Q is a radical of formula (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7), (b-8), wherein Alk is C1-6alkanediyl; Y1 is a bivalent radical of formula-NR2- or -CH(NR2R4)-; X1 is NR4, S, S(=O), S(=O)2, O, CH2, C(=O), CH(=CH2), CH(OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR5aR5b), CH2-NR4 or NR4-CH2; X2 is a direct bond, CH2, C(=O), NR4, C1-4alkyl-NR4, NR4-C1-4alkyl; t is 2 to 5; u is 1 to 5; v is 2 or 3; and whereby each hydrogen in Alk and in (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), may optionally be replaced by R3; provided that when R3 is hydroxy or C1-6alkyloxy, then R3 can not replace a hydrogen atom in the alpha position relative to a nitrogen atom; G is substituted C1-10alkanediyl wherein the substituent is attached via an oxygen atom; R1 is an optionally substituted monocyclic heterocycle or aryl; R2 is hydrogen, formyl, C1-6alkylcarbonyl, Hetcarbonyl, pyrrolidinyl, piperidinyl, homopiperidinyl, C3-7cycloalkyl or C1-10alkyl substituted with N(R6)2 and optionally with another substituent; R3 is hydrogen, hydroxy, C1-6alkyl, C1-6alkyloxy, arylC1-6alkyl or arylC1-6alkyloxy; R4 is hydrogen, C1-6alkyl or arylC1-6alkyl; R5a, R5b, R5c and R5d are hydrogen or C1-6alkyl; or R5a and R5b, or R5c and R5d taken together form a bivalent radical of formula -(CH2)s- wherein s is 4 or 5; R6 is hydrogen, C1-4alkyl, formyl, hydroxyC1-6alkyl, C1-6alkylcarbonyl or C1-6alkyloxycarbonyl; aryl is optionally substituted phenyl; Het is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl; as respiratory syncytial virus replication inhibitors; their preparation, compositions containing them and their use as a medicine.