发明名称 Method for administration of taxol
摘要 Taxol dosages of about 135 mg/m2 or greater are administered via infusions of less than 6 hours duration; the method makes it possible to provide taxol infusions on an out-patient basis to patients who do not otherwise require hospitalization. In a preferred embodiment, about 135 mg/m2 of taxol in a cremaphor emulsion is infused over a 3 hour duration, following patient pretreatment with steroids, antihistamines, and H2-receptor antagonists sufficient to prevent fatal anaphylactic-like reactions, and preferably sufficient to reduce the occurrence of severe anaphylactic-like reactions in greater than 90% of patients treated. In an alternative embodiment, between 135 mg/m2 and about 175 mg/m2 of taxol is provided in a 3-hour infusion, following pretreatment to minimize hypersensitivity responses. A method for rechallenging patients with taxol after episodes of acute hypersensitivity reactions is also disclosed, thus enabling patients to continue taxol therapy who would otherwise be deprived of treatment.
申请公布号 US6414014(B1) 申请公布日期 2002.07.02
申请号 US20000499373 申请日期 2000.02.07
申请人 BRISTOL-MYERS SQUIBB COMPANY 发明人 CANETTA RENZO MAURO;EISENHAUER ELIZABETH;ROZENCWEIG MARCEL
分类号 A61K45/00;A61K31/335;A61K31/337;A61K31/34;A61K31/40;A61K31/415;A61K31/425;A61K31/44;A61K31/54;A61K31/57;A61K38/19;A61K45/06;A61P35/00;A61P35/02;A61P37/08;(IPC1-7):A61K31/335 主分类号 A61K45/00
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