| 摘要 |
The invention provides an immunogenic particle comprising a plurality of copies of a first peptide monomer, said peptide monomer comprising a first discrete region and a second discrete region, said first region comprising an HBV pre-S1 epitope and said second region comprising a peptide which upon secretion will direct formation of particles that will provoke an immune response against the pre-S1 epitope, wherein said first peptide monomer constitutes more than five percent of all the protein in the particle and said particle is free of pre-S1 peptide. The particle is useful in the preparation of vaccines against hepatitis B virus. |
