Peptides Having For Example Antiangiogenic Activity and Applications Thereof In Therapeutics

摘要

The invention relates to cyclised peptides corresponding to sequence SEQ ID N^o 1: X₁X₂RGDX₃FGX₄X₅LLFIHFX₆IGSX₇HSX₈IX₉, wherein: the letters without any numerical index correspond to amino acids defined by the single-letter international code; X₁ is G or GG having an amino-terminal end which may or may not be free; X₂ is either a C, in which case X₂=X₄, the two Cs being connected by a disulphide bridge, or X₂ is capable of forming a lactam bridge with X₄, either X₂ or X₄ being an amino acid bearing an acid group, such as A or D, and the other bearing an amino function such as Q, N; X₃ is either an M pattern or a norleucine pattern; X₅ is one or several di-, tri-, or tetra-peptide patterns comprising G or a combination of G and S, or X₅ is a C pattern having a side-chain which serves as a covalent linkage point with a 3-nitro-2-pyridinesulphenyl group which is located at the N-terminal end of the next amino acid (L); X₆ is either an R pattern or a K pattern; X₇ is either an R pattern or a K pattern; X₈ is either an R pattern or a K pattern; and X₉ is an aliphatic amino acid (such as G or A) having an amide C-terminal end. The inventive peptides can be used as active ingredients in medicaments, for example, for the treatment of pathologies linked to hypervascularisation.