| 摘要 |
Cyclopropenylceramide derivatives as inhibitors of desaturases characterized by the general formula I in which R1 can be an alkyl, alkenyl, alkynyl, aryl or any heterocyclic group, n can have any value and it can be branched or straight chained and can contain unsaturated carbons and R2 and R3 can have the same or different values, and it can represent aryl, heteroaryl, alkyl or acyl groups with one or more unsaturated carbons on the chain, that can be branched or straight and substituted with OH groups. Members of this new class of compounds have shown an extraordinary activity as inhibitors of the dihydroceramide desaturase and of ceramide biosynthesis and are useful for the treatment of clinical conditions associated with increased intracellular ceramide. |
