5-(2-Substituted-5-hetreocyclysulphonyl pyrid-3-yl)-dihydropyrazoloÄ4,3-dÜpyrimidin-7ones as phosphidiesterase inhibitors

摘要

There is provided a compound of formula I:whereinX represents O or NR<5 >R<4 >represents H, halo, cyano, nitro, halo(loweralkyl), OR<6>, OC(O)R<7>, C(O)R<8>, C(O)OR<9>, C(O)NR<10>R<11>, NR<12>R<13>, NR<16>Y(O)R<17>, N[Y(O)R<17>]2, SOR<18>, SO2R<19>, C(O)AZ, lower alkyl, lower alkenyl, lower alkynyl, Het, alkylHet, aryl, alkylaryl (which latter seven groups are all optionally substituted with one or more substituents selected from halo, cyano, nitro, lower alkyl, halo(loweralkyl), OR<6>, OC(O)R<7>, C(O)R<8>, C(O)OR<9>, C(O)NR<10>R<11>, NR<12>R<13 >and SO2NR<14>R<15>)which are useful in the curative and prophylactic treatment of a medical condition for which inhibition of a cyclic guanosine 3',5'-monophosphate phosphodiesterase (e.g., cGMP PDE5) is desired.