| 发明名称 |
ANTICANCER COMBINATION COMPOSITIONS CONTAINING MITOIC INHIBITOR AND MEK INHIBITOR AND THEIR USE |
| 摘要 |
<p>Anticancer combination comprises a mitotic inhibitor and a MEK inhibitor. ACTIVITY : Cytostatic. MECHANISM OF ACTION : MEK inhibitor; mitotic inhibitor. In a cell culture assay using HT-29 colon carcinoma cells, paclitaxel and 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide produced a greater effect on apoptosis than the compounds alone.</p> |
| 申请公布号 |
HU0104844(A2) |
申请公布日期 |
2002.06.29 |
| 申请号 |
HU20010004844 |
申请日期 |
1999.12.21 |
| 申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
GOWAN RICHARD CARLETON;SEBOLT-LEOPOLD JUDITH |
| 分类号 |
A61K45/06;A61K31/135;A61K31/136;A61K31/165;A61K31/166;A61K31/18;A61K31/196;A61K31/245;A61K31/335;A61K31/337;A61K31/341;A61K31/35;A61K31/351;A61K31/352;A61K31/381;A61K31/40;A61K31/41;A61K31/4409;A61K31/4453;A61K31/475;A61K31/495;A61K31/5375;A61K35/00;A61P;A61P35/00;A61P43/00;C07D;(IPC1-7):A61P35/00 |
主分类号 |
A61K45/06 |
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