COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF

摘要

Compounds of formula (I) and salts and solvates are provided wherein R² is selected from phenyl substituted with n R¹ groups, and pyridyl substituted with n R¹ groups; n = 0, 1 or 2; each R¹ is independently selected from the group consisting of halo, C_1-4alkyl, C_1-4alkoxy, haloC_1-4alkyl, haloC_1-4alkoxy and cyano; R³ is selected from hydrogen and C_1-2 alkyl; R⁴ is selected from the group consisting of ethyl, n- propyl, i-propyl, n-butyl, i-butyl and t-butyl; or R³ and R⁴ together with the nitrogen atom to which they are attached form a saturated 5- or 6-membered heterocyclic ring optionally substituted with one or more groups X; each X is independently selected from the group consisting of C_1-4alkyl, and haloC_1-4alkyl; R¹² is selected from the group consisting of hydrogen, fluoro, chloro, bromo, methyl and methylthio; R¹³ is selected from hydrogen, chloro and trifluoromethyl; R¹⁴ is selected from hydrogen, trifluoromethyl and chloro; R¹⁵ is selected from hydrogen, chloro and trifluoromethyl; R¹⁶ is selected from hydrogen, methyl, fluoro and chloro; R¹², R¹³, R¹⁴, R¹⁵ and R¹⁶ not all simultaneously being hydrogen. Processes for the preparation and uses of the compounds as medicaments for treating disorders such as psychoses, dementia or attention deficit disorder are also disclosed.