The invention provides an attenuated enterobacterium comprising an attenuating mutation in the fnr gene, and optionally further comprising a heterologous nucleic acid encoding a foreign antigen. Also provided are pharmaceutical formulations comprising the attenuated enterobacteria of the invention. Further disclosed are methods of inducing an immune response in a subject by administration of an immunogenically effective amount of an attenuated enterobacterium or pharmaceutical formulation of the invention.
申请公布号
WO2008108805(A2)
申请公布日期
2008.09.12
申请号
WO2007US16357
申请日期
2007.07.19
申请人
NORTH CAROLINA STATE UNIVERSITY;HASSAN, HOSNI, M.;FINK, RYAN, C.;EVANS, MATTHEW, R.
发明人
HASSAN, HOSNI, M.;FINK, RYAN, C.;EVANS, MATTHEW, R.