摘要 |
Compounds of formula 1 wherein; R represents hydrogen, hydroxy, a group of formula OR7 wherein R7 is C1-C6 alkyl, C2-C6 alkenyl; R2 represents hydrogen, hydroxy, diethylamino, piperidino, tetrahydropyridino or morpholino; and either R3, taken alone, represents hydrogen or hydroxy, and R4 and R5, when taken alone, independently represent hydrogen, hydroxy or, taken together with the carbon atom, represent a carbonyl group; or R3 and R4, taken together, represent a group of formula 2 containing R8 and R9 wherein R8 and R9 represent a C1-C6 alkyl and R5 represents hydrogen; R6 represents hydrogen or a phenyl group, optionally substituted by methyl, methoxy or halogen, and the pharmaceutically acceptable salt thereof. The compounds are used in the treatment of AL amyloidosis, Alzheimer's disease or Down's syndrome.
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