发明名称 |
Modified amino acid sequence of receptor provide other ligands to bind and stabilise the active state conformation of the receptor |
摘要 |
Disclosed herein are techniques for directly identifying candidate compounds as agonists, partial agonists and/or, most preferably, inverse agonists, to endogenous, constitutively activated orphan G protein-coupled receptors. Such directly identified compounds can be utilized, most preferably, in pharmaceutical compositions.
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申请公布号 |
NZ509429(A) |
申请公布日期 |
2002.06.28 |
申请号 |
NZ19990509429 |
申请日期 |
1999.07.30 |
申请人 |
ARENA PHARMACEUTICALS, INC |
发明人 |
BEHAN, DOMINIC P;CHALMERS, DEREK T;LIN, I-LIN;LIAW, CHEN;LOWITZ, KEVIN;CHEN, RUOPING |
分类号 |
G01N33/50;A61K45/00;A61P43/00;C07D233/42;C07D403/12;C07D405/12;C07D409/12;C07D413/12;C07D513/04;C12N15/09;G01N33/15;G01N33/566;G01N33/68;(IPC1-7):C07K14/00 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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